Structure of Multidrug Resistance Transporters
نویسندگان
چکیده
منابع مشابه
Structure and function of multidrug transporters.
全ての生物は細胞から構成されている。そして全ての 細胞の表面は細胞膜によって包まれている。細胞膜はリ ン脂質によって構成されるため,その中央付近は誘電率 が極めて低く,イオンや,極性物質を透過させることが できない。そのため細胞膜は細胞と外界を隔てる障壁と して働き,細胞質を外部環境と異なる状態に維持する。 また細胞膜中や,細胞膜表面には多くの膜蛋白質が存在 し,種々の生理的に重要な反応を行っている。透過障壁 である細胞膜を介した物質の輸送,すなわち膜輸送は極 めて基本的な生理現象である。それは細胞膜に存在する 種々のチャネル,ポンプや,トランスポーター(膜輸送 体)と呼ばれる膜蛋白質を介して行われる。一般にチャ ネルとポンプは,イオンを輸送し,トランスポーターは 栄養素や薬剤等の有機物質を輸送すると類別されてい る。また,チャネルは受動的なイオンの流入を司り,ポ ンプとトランスポー...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.3000